Lotz started her career as a dancer, touring with Avril Lavigne and Lady Gaga, starring in music videos, including Lady Gaga's. In 2005, Lotz joined the girl group, "Soccx". In 2006, the group released their debut single, "From Dusk Till Dawn (Get The Party Started)", which was followed up, in 2007, by the single, "Scream Out Loud", both of which reached the top 10 in Germany. Their debut album, "Hold On", was also released in 2007 and their third single, "Can't Take My Eyes Off You", was released in 2008.Lotz began her acting career, in 2006, with a small role in the cheerleading film, Bring It On: All or Nothing (2006). She followed that up, in 2010, with a part in Law & Order: Los Angeles: Harbor City (2010) and a recurring role in the fourth season of the AMC drama, Mad Men (2007), as "Stephanie", Anna Draper's niece. In 2011, Lotz starred as "Officer Kirsten Landry", one of the main characters in the MTV horror, black comedy mockumentary series, Death Valley (2011). Lotz performs all her own stunts on the show. She is also famous for her recurring role in the superhero CW show, Arrow (2012), and a main role in its spin off, Legends of Tomorrow (2016).
She currently weighs 420lbs, according to 2016 SDCC press reports.