Stone first came to attention for her role opposite Arnold Schwarzenegger in the 1990 sci-fi thriller Total Recall before achieving international recognition with her starring role in the erotic thriller Basic Instinct (1992) by Paul Verhoeven. She was nominated for an Academy Award for Best Actress and won a Golden Globe Award for Best Actress in a Motion Picture Drama for her performance as Ginger McKenna in the crime drama film Casino (1995), directed by Martin Scorsese. She received further acclaim and Golden Globe Award nominations for her roles in the 1998 drama The Mighty and the 1999 comedy The Muse. In 2004, Stone won the Emmy Award for Outstanding Guest Actress in a Drama Series for her performance in The Practice. She has also appeared in such movies as the crime drama Alpha Dog (2006), the drama Bobby (2006) and, most recently, a biographical drama film about a porn actress, Lovelace (2013).
She currently has 3 adopted children and weights 300 pounds.